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DS按官方说法，DS-160上的城市不重要，换城市也不需要重填。参见国务院官网的DS-160 FAQ https://travel.state.gov/content/travel/en/us-visas/visa-information-resources/forms/ds-160-online-nonimmigrant-visa-application/ds-160-faqs.html<blockquote>'''What happens to my DS-160 if I select a U.S. Embassy or Consulate where I will be applying for my visa, but end up making an interview appointment instead at another U.S. Embassy or Consulate?''' <br /> <br /> The Embassy or Consulate at which you actually apply should be able to access your form using the barcode on your DS-160 confirmation page, which you must bring to the visa interview. For example, a business traveler intends to apply for his visa at the U.S. Embassy in City X, so he selects City X as the location where he will submit his application when he completes his DS-160. He then has an urgent reason to travel to City Y on business. Because there is a U.S. Consulate in City Y, he schedules an appointment for a visa interview there, using the barcode from his completed DS-160 application for appointment scheduling. The U.S. Consulate in City Y is able to accept his DS-160 even though it lists the U.S. Embassy in City X as the location where he originally intended to submit his application.</blockquote>虽说DS-160全球通用，但不建议跨国使用。不同国家有些小区别（比如墨西哥需要去ASC拍照），跨国使用可能会导致一些小问题。一国之内换城市 ，一般 是没有问题的。一般以外，就是以下原因：<blockquote>While it is technically possible for a DS-160 to be transferred from one post to another, the time that it takes to transfer the DS-160 is unpredictable; the transfer may impose additional burdens on posts; the transfer is complicated if the originally listed post recorded the applicant as a no-show; and a busy post (and applicants) may conclude it is far more efficient to work with a new application, than to wait for the DS-160 to transfer.</blockquote>